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X-WR-RELCALID:www_embl_org_seminar_13097.ics
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DTSTAMP:20210118T002447Z
LOCATION:Virtual seminar\, EMBL Rome\, Adriano Buzzati-Traverso Campus\, Vi
 a Ramarini 32\, 00015 Monterotondo\, Italy
SUMMARY;LANGUAGE=en-us:Joan Barau: Learning the ABC of germline development
 al epigenetics
DESCRIPTION:External Faculty Speaker\nSpeaker: Joan Barau\nInstitution: Ins
 titute of Molecular Biology (IMB)\nMainz\, Germany\nHost: Cornelius Gross\
 nAbstract: Cytosine DNA methylation is a dynamic\, bona fide epigenetic mo
 dification of the mammalian genome that plays important roles in regulatin
 g development and safeguarding reproduction. The gametic DNA methylation p
 atterns are thought to be established by the de novo DNA methyltransferase 
 enzymes\, DNMT3A and DNMT3B\, both deemed essential for fertility based on 
 their specific and redundant activities. We have described a novel murine 
 DNA methyltransferase enzyme\, DNMT3C which was found to be essential for 
 male fertility through the DNA methylation-dependent silencing of transpos
 able elements. The discovery of DNMT3C challenged our previous understandi
 ng of the contributions of DNMT3A and DNMT3B and the roles of DNA methylat
 ion in spermatogenesis. In this seminar\, I will present our ongoing effor
 ts to characterize the individual roles of the de novo DNA methyltransfera
 ses in spermatogenesis\, in understanding how they are targeted to specifi
 c genomic regions\, and the consequences of different DNA methylation defe
 cts in male germ cells.\n
DTSTART:20210115T100000Z
LAST-MODIFIED:20210118T002447Z
DURATION:PT1H
UID:www.embl.org/13097
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